Prof. dr hab. Adam Huczyński

Education and career:

  • Since the 1st of September, 2019 –  full professor at the Adam Mickiewicz University, Poznań.
  • 01-04-2016 – 31-09-2019 associate professor at the Adam Mickiewicz University, Poznań.
  • 2013 – award of habilitation degree on presentation of a dissertation based on a monothematic series of 24 papers published after doctorate, entitled ”Synthesis, spectroscopic and structural studies of modified ionophore antibiotics and evaluation of their antimicrobial and anticancer activity” (habilitation degree awarded on the 24th of May, 2013, habilitation procedure at the Faculty of Chemistry, Adam Mickiewicz University, Poznań. The habilitation dissertation was distinguished with Wiktor Kemula award for the best habilitation dissertation in 2014 by the Polish Chemical Society.
  • 2004-2008 Doctor of Science in Chemistry. I graduated from 4 year doctoral studies at the Faculty of Chemistry, Adam Mickiewicz University, Poznań. Doctoral dissertation on ”Synthesis, spectroscopic and semiempirical studies of Monensin A esters and their complexes with metal cations” prepared under promotion of Prof. Dr hab. Bogumił Brzezinski (public defense on 28.05.2008). The doctoral dissertation was distinguished as the best doctoral dissertation with Aleksander Zamojski Award by the Polish Chemical Society and with the Award of the Dean of the Faculty of Chemistry, AMU.
  • 1999-2004 Master of Science in Chemistry. I graduated from 5 year studies of chemistry at the Faculty of Chemistry, Adam Mickiewicz University, Poznań. Master’s degree dissertation on ”Synthesis and physicochemical properties of new fluorescent derivatives of 6-amino-2-thiouracil” was written at the Laboratory of Mass Spectrometry of Organic Compounds under promotion of Prof. Dr hab. Elżbieta Wyrzykiewicz. I graduated with maxima cum laude.
  • 2002-2004 Master of Science in Physics. I graduated from 2 year studies at the Faculty of Physics, Adam Mickiewicz University, Poznań, with a master’s degree in physics upon presentation of a dissertation ”Fluorescence labeling of proteins and their use in the fluorescence correlation spectroscopy”, written in Department of Molecular Biophysics under promotion of Prof. Dr hab. Adam Patkowski.
  • 1999-2002 Licentiate in Physics. 3 year studies at the Faculty of Physics, Adam Mickiewicz University, Poznań
  • 1994-1999 Chemistry Technician, specialist in chemical analysis. High School with profile in chemical technology, in the Group of Chemical High Schools in Poznań.

Honors and awards

  • The Award of Polish Chemical Society, Wiktor Kemula Award (the competition for the best habilitation, 2014),
  • Stipends from the Polish Minister of Science and Higher Education for outstanding young scientists (2011-2013),
  • Scholarship from the German Academic Exchange Service (DAAD) (2012),
  • The Award of Polish Chemical Society (the competition for the best doctoral thesis, 2009),
  • Stipends from Foundation of Polish Science (FNP) for young researchers (2007, 2008),
  • Scholarship from the city of Poznan (2008).

Latest Publications

Peer Reviewed Research Papers (in reverse chronological order)

  1. Nowak, D., Huczyński, A., Bachorz, R.A., Hoffmann, M. Machine Learning Application for Medicinal Chemistry: Colchicine Case, New Structures, and Anticancer Activity Prediction (2024) Pharmaceuticals 17, 173.
  2. Przybył, A.K., Janczak, J., Huczyński, A. Molecular structure and spectroscopic studies of (−)-cytisine salt with (+)-tartaric acid (2024) Journal of Molecular Structure, 1304, art. no. 137704.
  3. Sulik, M., Fontinha, D., Steverding, D., Sobczak, S., Antoszczak, M., Prudêncio, M., Huczyński, A. Unexpected rearrangement of ivermectin in the synthesis of new derivatives with trypanocidal and antiplasmodial activities (2024) European Journal of Medicinal Chemistry, 263, art. no. 115951.
  4. Sulik, M., Antoszczak, M., Huczyński, A., Steverding, D. Antiparasitic activity of ivermectin: Four decades of research into a “wonder drug” (2023) European Journal of Medicinal Chemistry, 261, art. no. 115838.
  5. Markowska, A.,  Antoszczak, M., Kacprzak, K., Markowska, J., Huczyński, A. Role of Fisetin in Selected Malignant Neoplasms in Women (2023) Nutrients, 15(21), 4686.
  6. Markowska, A., Antoszczak, M., Markowska, J., Huczyński, A. The Role of Selected Dietary Factors in the Development and Course of Endometriosis, (2023) Nutrients, 15(12), art. no. 2773.
  7. Antoszczak, M., Gadsby-Davis, K., Steverding, D., Huczyński, A. Synthesis of urea and thiourea derivatives of C20-epi-aminosalinomycin and their activity against Trypanosoma brucei (2023) European Journal of Medicinal Chemistry, 250, art. no. 115241.
  8. Markowska, A., Antoszczak, M., Markowska, J., Huczyński, A. Role of Hyaluronic Acid in Selected Malignant Neoplasms in Women (2023) Biomedicines, 11(2), art. no. 304.
  9. Steverding, D., Strand, D., Huczyński, A. Trypanocidal and cell swelling activity of 20-deoxysalinomycin, (2022) Experimental Parasitology, 243, 108414.
  10. Markowska, A., Antoszczak, M., Markowska, J., Huczyński, A. Role of Vitamin K in Selected Malignant Neoplasms in Women (2022) Nutrients 14, no. 16: 3401.
  11. Czerwonka, D., Podsiad, M., Stefańska, J., Antoszczak, M., Huczyński, A. Activity of singly and doubly modified derivatives of C20-epi-salinomycin against Staphylococcus strains (2022) Journal of Antibiotics, 75(8), 445-453.
  12. Urbaniak, A., Reed, M.R., Heflin, B., Gaydos, J., Piña-Oviedo, S., Jędrzejczyk, M., Klejborowska, G., Stępczyńska, N., Chambers, T.C., Tackett, A.J., Rodriguez, A., Huczyński, A., Eoff, R.L., MacNicol, A.M. Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer (2022) Biomedicine and Pharmacotherapy, 153, art. no. 113440
  13. Jędrzejczyk, M., Janczak, J., Huczyński, A. Molecular structure and spectroscopic studies of the product of acidic degradation of salinomycin and its potassium salt (2022) Journal of Molecular Structure, 1263, art. no. 133129.
  14. Antonenko, Y.N., Jędrzejczyk, M., Rokitskaya, T.I., Khailova, L.S., Kotova, E.A., Huczyński, A. Rate of translocation across lipid bilayer of triphenylphosphonium-linked salinomycin derivatives contributes significantly to their K+/H+ exchange activity on membranes, (2022) Bioelectrochemistry, 145, art. no. 108089
  15. Antoszczak, M., Otto-Ślusarczyk, D., Kordylas, M., Struga, M., Huczyński, A. Synthesis of Lasalocid-Based Bioconjugates and Evaluation of Their Anticancer Activity (2022) ACS Omega, 7 (2), pp. 1943-1955.
  16. Markowska, A., Antoszczak, M., Markowska, J., Huczyński, A. Role of Vitamin C in Selected Malignant Neoplasms in Women (2022) Nutrients, 14 (4), art. no. 882.
  17. Jędrzejczyk, M., Stępczyńska, N., Klejborowska, G., Podsiad, M., Stefańska, J., Steverding, D., Huczyński, A. Synthesis and evaluation of antibacterial and trypanocidal activity of derivatives of monensin A (2022) Bioorganic and Medicinal Chemistry Letters, 58, art. no. 128521.
  18. Markowska, A., Antoszczak, M., J Markowska, J., Huczyński, A.  Role of Vitamin E in Selected Malignant Neoplasms in Women (2022) Nutrition and Cancer, 74 (4), 1163-1170.
  19. Krzywik, J., Nasulewicz-Goldeman, A., Mozga, W.,  Wietrzyk, J., Huczyński, A. Novel Double-Modified Colchicine Derivatives Bearing 1,2,3-Triazole: Design, Synthesis, and Biological Activity Evaluation, (2021) ACS Omega 6 (40), 26583-26600.
  20. Czerwonka, D., Maj, E., Wietrzyk, J., Huczyński, A. Synthesis of thiocolchicine amine derivatives and evaluation of their antiproliferative activity, (2021) Bioorganic and Medicinal Chemistry Letters, 52, 128382.
  21. Krzywik, J., Maj, E., Nasulewicz-Goldeman, A., Mozga, W., Wietrzyk, J., Huczyński, A. Synthesis and antiproliferative screening of novel doubly modified colchicines containing urea, thiourea and guanidine moieties (2021) Bioorganic and Medicinal Chemistry Letters, 47, 128197.
  22. Czerwonka, D., Mielczarek-Puta, M., Antoszczak, M., Cioch, A., Struga, M., Huczyński, A. Evaluation of the anticancer activity of singly and doubly modified analogues of C20-epi-salinomycin (2021) European Journal of Pharmacology, 908, 174347.
  23. Urbaniak, A., Reed, M.R., Fil, D., Moorjani, A., Heflin, S., Antoszczak, M., Sulik, M., Huczyński, A., Kupsik, M., Eoff, R.L., MacNicol, M.C., Chambers, T.C., MacNicol, A.M. Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models (2021) Biomedicine and Pharmacotherapy, 141, 111815.
  24. Krzywik, J., Aminpour, M., Janczak, J., Maj, E., Moshari M., Mozga W., Wietrzyk, J., Tuszyński, J.A., Huczyński, A. An insight into the anticancer potential of carbamates and thiocarbamates of 10-demethoxy-10-methylaminocolchicine, (2021) European Journal of Medicinal Chemistry, 113282.
  25. Klejborowska, G., Urbaniak, A., Maj, E., Wietrzyk, J., Moshari, M., Preto, J., Tuszynski, J.A., Chambers, Huczyński, A. Synthesis, anticancer activity and molecular docking studies of N-deacetylthiocolchicine and 4-iodo-N-deacetylthiocolchicine derivatives, (2021) Bioorganic & Medicinal Chemistry, 32, 116014.
  26. Czerwonka, D., Sobczak, S., Pędziński, T., Maj, E., Wietrzyk, J., Celewicz, L., Katrusiak, A., Huczyński, A. Photoinduced Skeletal Rearrangement of N-Substituted Colchicine Derivatives, (2021) Journal of Organic Chemistry, 86 (16), 11029–11039.
  27. Kuran, D., Flis, S., Antoszczak, M., Piskorek, M.,  Huczyński, A. Ester derivatives of salinomycin efficiently eliminate breast cancer cells via ER-stress-induced apoptosis, (2021) European Journal of Pharmacology, 893, 173824.
  28. Urbaniak, A., Piña-Oviedo, S., Yuan, Y., Huczyński, A.,  Chambers, T. C. Limitations of an ex vivo breast cancer model for studying the mechanism of action of the anticancer drug paclitaxel, (2021) European Journal of Pharmacology, 891, 173780.
  29. Czerwonka, D., Barcelos, Z., Steverding, D., Cioch, A., Huczyński, A., Antoszczak, M. Singly and doubly modified analogues of C20-epi-salinomycin: A new group of antiparasitic agents against Trypanosoma brucei, (2021) European Journal of Medicinal Chemistry, 209, 112900.
  30. Antoszczak, M., Markowska, A., Markowska, J., Huczyński, A. Antidepressants and antipsychotic agents as repurposable oncological drug candidates, (2021) Current Medicinal Chemistry, 28 (11) 2137 – 2174.
  31. Markowska, A., Antoszczak, M., Markowska, J., Huczyński, A. Statins: HMG-CoA Reductase Inhibitors as Potential Anticancer Agents against Malignant Neoplasms in Women, (2020) Pharmaceuticals, 13, 422.
  32. Markowska, A., Antoszczak, M., Kojs, Z., Bednarek, W., Markowska, J., Huczyński A. Role of vitamin D3 in selected malignant neoplasms, (2020) Nutrition, Vol . 79-80, 110964.
  33. Krzywik, J., Aminpour, M., Maj, E., Mozga, W., Wietrzyk, J., Tuszyński, J.A., Huczyński, A. New Series of Double-Modified Colchicine Derivatives: Synthesis, Cytotoxic Effect and Molecular Docking. (2020) Molecules, 25, 3540.
  34. Sulik, M., Maj, E., Wietrzyk, J., Huczyński, A., Antoszczak M. Synthesis and Anticancer Activity of Dimeric Polyether Ionophores. (2020) Biomolecules, 10(7):1039.
  35. Krzywik, J., Mozga, W., Aminpour, M., Janczak, J., Maj, E., Wietrzyk, J., Tuszyński, J.A., Huczyński, A. Synthesis, Antiproliferative Activity and Molecular Docking Studies of Novel Doubly Modified Colchicine Amides and Sulfonamides as Anticancer Agents (2020)  Molecules , 25, 1789.
  36. Czerwonka, D., Sobczak, S., Maj, E., Wietrzyk, J., Katrusiak, A., Huczyński, A. Synthesis and Antiproliferative Screening Of Novel Analogs of Regioselectively Demethylated Colchicine and Thiocolchicine  (2020) Molecules, 25, 1180.
  37. Sulik, M., Stępień, K., J. Stefańska, Huczyński, A., Antoszczak, M. Antibacterial activity of singly and doubly modified salinomycin derivatives (2020) Bioorg. Med. Chem. Lett. 30(9), 127062.
  38. Klejborowska, G., Urbaniak, A., Maj, E., Preto, J., Moshari, M., Wietrzyk, J., Tuszynski, J.A., Chambers T.C., Huczyński, A. Synthesis, biological evaluation and molecular docking studies of new amides of 4-chlorothiocolchicine as anticancer agents (2020) Bioorg. Chem., 97, 103664.
  39. Pallante, L., Rocca, A., Klejborowska, G., Huczynski, A., Grasso, G., Tuszynski, J. A.,  Deriu, M. A. In silico Investigations of the Mode of Action of Novel Colchicine Derivatives Targeting β-Tubulin Isotypes: A Search for a Selective and Specific β-III Tubulin Ligand (2020) Frontiers in Chemistry, 8, 108.
  40. Michalak, M., Lach, M.S., Antoszczak, M., Huczynski, A., Suchorska, W.M. Overcoming resistance to platinum-based drugs in ovarian cancer by salinomycin and its derivatives—an in vitro study (2020) Molecules, 25 (3), art. no. 537.
  41. Czerwonka, D., Urbaniak, A., Sobczak, S., Piña-Oviedo, S., Chambers, T.C., Antoszczak, M., Huczyński, A. Synthesis and Anticancer Activity of Tertiary Amides of Salinomycin and Their C20-oxo Analogues (2020) ChemMedChem, 15 (2), pp. 236-246.
  42. Antoszczak, M., Markowska, A., Markowska, J., Huczyński, A. Old wine in new bottles: Drug repurposing in oncology (2020) European Journal of Pharmacology, 866, art. no. 172784.
  43. Alqahtani, T., Kumarasamy, V.M., Huczyński, A., Sun, D. Salinomycin and its derivatives as potent RET transcriptional inhibitors for the treatment of medullary thyroid carcinoma (2020) International Journal of Oncology, 56 (1), pp. 348-358.
  44. Klejborowska, G., Moshari, M., Maj, E., Majcher, U., Preto, J., Wietrzyk, J., Tuszynski, J.A., Huczyński, A. Synthesis, antiproliferative activity, and molecular docking studies of 4-chlorothiocolchicine analogues (2020) Chemical Biology and Drug Design, 95 (1), pp. 182-191.
  45. Klejborowska, G., Urbaniak, A., Preto, J., Maj, E., Moshari, M., Wietrzyk, J., Tuszynski, J.A., Chambers, T.C., Huczyński, A. Synthesis, biological evaluation and molecular docking studies of new amides of 4 bromothiocolchicine as anticancer agents (2019) Bioorganic and Medicinal Chemistry, 27 (23), art. no. 115144.
  46. Klejborowska, G., Jędrzejczyk, M., Stępczyńska, N., Maj, E., Wietrzyk, J., Huczyński, A. Antiproliferative activity of ester derivatives of monensin A at the C-1 and C-26 positions (2019) Chemical Biology and Drug Design, 94 (4), pp. 1859-1864.
  47. Antoszczak, M., Huczyński, A. Salinomycin and its derivatives – A new class of multiple-targeted “magic bullets (2019) European Journal of Medicinal Chemistry, 176, pp. 208-227.
  48. Markowska, A., Kaysiewicz, J., Markowska, J., Huczyński, A. Doxycycline, salinomycin, monensin and ivermectin repositioned as cancer drugs (2019) Bioorganic and Medicinal Chemistry Letters, 29 (13), pp. 1549-1554.
  49. Antoszczak, M., Steverding, D., Sulik, M., Janczak, J., Huczyński, A. Anti-trypanosomal activity of doubly modified salinomycin derivatives (2019) European Journal of Medicinal Chemistry, 173, pp. 90-98.
  50. Antoszczak, M., Steverding, D., Huczyński, A. Anti-parasitic activity of polyether ionophores (2019) European Journal of Medicinal Chemistry, 166, pp. 32-47.
  51. Urbaniak, A., Jousheghany, F., Yuan, Y., Pina-Oviedo, S., Huczynski, A., Delgado, M., Kieber-Emmons, T., Monzavi-Karbassi, B., Chambers, T.C. The response of phyllodes tumor of the breast to anticancer therapy: An in vitro and ex vivo study (2019) Oncology Letters, 18 (5), pp. 5097-5106.
  52. Majcher, U., Urbaniak, A., Maj, E., Moshari, M., Delgado, M., Wietrzyk, J., Bartl, F., Chambers, T.C., Tuszynski, J.A., Huczyński, A. Synthesis, antiproliferative activity and molecular docking of thiocolchicine urethanes (2018) Bioorganic Chemistry, 81, pp. 553-566.
  53. Kacprzak, K., Ruszkowski, P., Valentini, L., Huczyński, A., Steverding, D. Cytotoxic and trypanocidal activities of cinchona alkaloid derivatives (2018) Chemical Biology and Drug Design, 92 (4), pp. 1778-1787.
  54. Antoszczak, M., Urbaniak, A., Delgado, M., Maj, E., Borgström, B., Wietrzyk, J., Huczyński, A., Yuan, Y., Chambers, T.C., Strand, D. Biological activity of doubly modified salinomycin analogs – Evaluation in vitro and ex vivo (2018) European Journal of Medicinal Chemistry, 156, pp. 510-523.
  55. Klejborowska, G., Maj, E., Wietrzyk, J., Stefańska, J., Huczyński, A. One-pot synthesis and antiproliferative activity of novel double-modified derivatives of the polyether ionophore monensin A (2018) Chemical Biology and Drug Design, 92 (2), pp. 1537-1546.
  56. Markowska, A., Sajdak, S., Huczyński, A., Rehlis, S., Markowska, J. Ovarian cancer stem cells: A target for oncological therapy (2018) Advances in Clinical and Experimental Medicine, 27 (7), pp. 1017-1020.
  57. Urbaniak, A., Delgado, M., Antoszczak, M., Huczyński, A., Chambers, T.C. Salinomycin derivatives exhibit activity against primary acute lymphoblastic leukemia (ALL) cells in vitro (2018) Biomedicine and Pharmacotherapy, 99, pp. 384-390.
  58. Majcher, U.; Klejborowska, G.; Kaik, M.; Maj, E.; Wietrzyk, J.; Moshari, M.; Preto, J.; Tuszynski, J.A.; Huczyński, A. Synthesis and Biological Evaluation of Novel Triple-Modified Colchicine Derivatives as Potent Tubulin-Targeting Anticancer Agents (2018) Cells 7, 216.
  59. Markowska, A., Sajdak, S., Markowska, J., Huczyński, A. Could there be a role for the antidiabetic drug metformin in oncological treatment? (2018) European Journal of Gynaecological Oncology, 39 (6), pp. 867-870.
  60. Majcher, U., Klejborowska, G., Moshari, M., Maj, E., Wietrzyk, J., Bartl, F., Tuszynski, J.A., Huczyński, A. Antiproliferative Activity and Molecular Docking of Novel Double-Modified Colchicine Derivatives. (2018) Cells 7, 192.
  61. Markowska, A., Sajdak, S., Markowska, J., Huczyński, A. Angiogenesis and cancer stem cells: New perspectives on therapy of ovarian cancer (2017) European Journal of Medicinal Chemistry, 142, pp. 87-94.

Full List of Publications:

Patents:

Chemistry Tree – the Academic Genealogy of Chemistry Researchers