Nowa praca na temat modyfikacji kolchicyny

Greta Klejborowska, Alicja Urbaniak, Ewa Maj, Jordane Preto, Mahshad Moshari, Joanna Wietrzyk, Jack A. Tuszynski, Timothy C. Chambers, Adam Huczyński,
„Synthesis, biological evaluation and molecular docking studies of new amides of 4-chlorothiocolchicine as anticancer agents”, Bioorganic Chemistry, 2020, 97, 103664,

Synthesis, biological evaluation and molecular docking studies of new amides of 4-chlorothiocolchicine as anticancer agents

The comparison of selectivity index (SI) values of tested compounds. SI was calculated for each compound using the formula: SI = IC₅₀ for normal cell line BALB/3T3 / IC₅₀ for respective cancerous cells or cell line. A beneficial SI > 1.0 indicates a drug with efficacy against tumor cells greater than the toxicity against normal cells.

https://doi.org/10.1016/j.bioorg.2020.103664